我们相信强大的搜索功能对任何SNP标记数据库都是必须的。就我们的经验而言，研究者对任何基因标记都会有需求：SNP识别号，微卫星识别号，基因座区甚至基因和蛋白质识别号。开发一个便利的SNP搜索功能,能为用户提供基因标记输入和过滤功能的SNP列表。这是通过不同的数据库象dbsnp,Unists,NCBI ideogram,genome assemely和HapMapⅡproject整合的。
0 W3 F) A9 I5 n6 j  q$ }# ?/ v( p- ]& Y$ X% }4 t4 ]) H  C

" {  ~6 x7 F5 \% a5 U! e- Y. n- U
7 i: ?0 Q* @+ X) Z( r

9 C8 X; o( n' N5 x

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Table 1. SNP功能入口的功能标记1 g4 F1 i5 c! H: G3 v" ?

Genome Level ( K- c2 D$ m# p% C) o' |) t0 G
- c- {0 w, g7 s3 j" @/ e

0 f; Z7 u& D2 N' c: r5 C; S3 EConserved Genomic Region

Repetitive Sequence

Transcript Level
6 Z. u9 X+ K, t$ S6 F& h" u+ a& UCpG Island

DNase 1 Hypersensitive Site
" T9 V, L9 i( t8 oHistone Acetylation Site' A* w& S8 G$ j7 ~
Known Transcription Factor Binding Site$ i/ ]' U' q% g8 J! ^, T# O$ B9 r
Predicted Transcription Factor Binding Site
' E; z- D9 p3 R4 d! `( }. }9 I$ }' F  kRNA Polymerase Binding Region
" a& T/ m% ~- y6 \Splicing donar/acceptor sites
, @+ U2 a% K# [) DIntronic and Exonic Splice Enhancer/Silencer
: o7 A7 x: v7 hBranch Site Recognition Sequence
7 k1 N7 C, \  uMicroRNA Transcript, I- P* m1 @8 v% W, W) O
MicroRNA Binding Site/ ]- S: K/ P  n4 t% z

RNA Stability

Protein Level
5 f* U; S/ G4 G) v1 D3 y
" z9 |9 s3 S2 {+ u! r* DInternal Ribosomal Entry Site
# P5 J9 d, L  Q( `3 [5 `' iKnown Or Potential Modification Site,
* s' f8 ?5 D- W% j, ]1 p* sIncluding Phosphorylation, Sulfation,
  W# {+ Z& w, t) w2 hMethylation, Acetylation, Palmitylation,2 y% a7 U8 Y+ e! \
Myristoylation, Glycosylation, etc1 ^$ ?) ~9 L- ^- X5 a
Key Residues Influence
- a. \9 ^( a1 M9 y2 EProtein Domain Structure5 Z4 W& V6 f2 e- O  t# D9 W$ ]
Protein Location Motif: Signal Peptide,6 n7 o. u7 U8 o7 d* T0 V
Nuclear Localization Signal
6 N2 F, }1 b/ d$ D( g0 \Conserved Protein Domain. j6 I/ w) u" _; ^# y9 M
Activity/Binding Center Of Protein
8 S: N: c, ]- q" ~! r; D' x- X! aProtein-Protein Interaction Interface& ]* t+ V6 j* _) N' b5 p
Pathway/Ontology Level 8 A* A3 m( O- l/ N, W1 d! F
6 C4 l/ E2 l1 G) p
Gene Ontology
" S2 f3 t8 A5 `% z+ l* O5 jKEGG Pathway; g( z/ N( p4 B( T* x# r
BioCarta Pathway) {$ C/ |. `1 N6 v
Molecular Interaction Network
3 L7 C/ d& N0 eDisease Level
. P' S8 T- p# u$ v! {& A- a, L9 T
$ p) R, [0 R, D/ a( v# t' l
3 X3 k+ `6 h+ _) m4 }& e( o' q! iOMIM annotation
. I  v, u9 m8 Q) g, c. ], g  wLiterature description+ w, V5 c8 G% r- _- S* O
Association Statistics
: N& `! z- A; L5 x, z3 B) T) [2 eLinkage Statistics
: p+ W( t  A% X5 t+ v* bSNP-SNP Interaction Statistics: U% M+ P, c! `8 s% f& O
Expression Profile- _# `* A' Z! s5 n
Population " _- L2 ?; U4 L& ^9 x9 O. x9 g
2 T  e/ ^/ R6 ~3 Z4 p2 y" _% O
5 f$ ?; s( f, x* \
Linkage Disequilibrium Scores
! `, Q9 g: a1 T( q3 VGenetics Level
0 u* W, ?# f; g0 I
; j2 P+ O* V) A
! j$ z& m! p+ _2 ?* d2 X4 ?Haplotype; r+ q& v5 t" q1 H5 Y
Ancestral Allele# y; @; q8 g2 Y- i4 k4 X
Tajima’s D0 o" V% e7 k) y, J6 w, u8 M& i4 p( e* s
Fst Value
8 t) j' t0 Q; Q4 E1 D6 ~Heterozygosity
0 d5 I0 g0 @/ c& k& f# jAllele Frequency
7 I+ h% C; e& v/ m, gMap Weight, N; z7 z) c4 s. }1 n- o# g, B7 T

*红色是SNP标记信息数据库的六大分类.具体标记细化黑色9 S) a6 Q' u7 z9 ^% F

& H* Z7 {  s& C3 ]9 e; W2 E' S5 m  z[ 本帖最后由 ghost8469 于 07-9-27 22:30 编辑 ]