一篇来自PLos的关于表位的免疫信息学的综述,详细介绍了关于T/B细胞表位预测的在线工具以及相关的表位信息,MHC特异基序等信息的数据库.
Immunoinformatics Comes of Age
ABSTRACT
With the burgeoning immunological data in the scientific literature, scientists must increasingly
rely on Internet resources to inform and enhance their work. Here we provide a brief overview of the adaptive immune response and summaries of immunoinformatics resources, emphasizing those with Web interfaces. These resources include searchable databases of epitopes and immune-related molecules, and analysis tools for T cell and B cell epitope prediction, vaccine design, and protein structure comparisons. There is an agreeable synergy between the growing collections in immune-related databases and the growing sophistication of analysis software; the databases
provide the foundation for developing predictive computational tools, which in turn enable more rapid identification of immune responses to populate the databases. Collectively, these resources contribute to improved understanding of immune responses and escape, and evolution of pathogens under immune pressure. The public health implications are vast, including designing
vaccines, understanding autoimmune diseases, and defining the correlates of immune protection.
